Scientists at MIT and Harvard University have finally figured out how the key gene tied to obesity makes people fat, a major discovery that could open the door to an entirely new approach to the problem beyond diet and exercise. The FTO gene turns out to influence obesity indirectly, as a master switch that affects two other genes that control thermogenesis, or burning off energy. Experiments reveal that a faulty version of the FTO gene causes energy from food to be stored as fat rather than burned.

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