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Asbestos Exposure – A Deadly Result
Asbestos is a well-known human carcinogen. Exposure to asbestos may increase the risk of mesothelioma, a relatively rare cancer of the thin membranes that line the chest and abdomen.
Through a combination of second-generation sequencing and cutting-edge bioinformatics approaches, a large deletion was found within the DPP10 (di-peptidyl peptidase) gene. This deletion results in reduced expression of DPP10 and is associated with poor patient survival.
DPP10 encodes a type II transmembrane protein that is known to modulate potassium channels and alter their expression and biophysical properties. It may influence tumour cell survival or growth, as potassium channels are known to play important roles in regulating cell proliferation, cell cycle progression and apoptosis.
The deletion within the region on DPP10 can be observed using our SynaSV application. SynaSV is an online tool specifically designed to visualise and classify structural variations. This application can be used to analyse both single and paired-end reads.
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