What We Offer

Analyse the human genome with MGRC's Human Genome Bioinformatics Service.

For a special offer starting from only US $4000, we map sequenced data up to 30x coverage of the human genome, identify mutations and present the results and findings in a compact report and an online browser.

Our comprehensive service gives you the freedom to focus on your human genome sequencing project without having to worry about high costs in terms of money, manpower, resources and time.

This service is specifically designed for data generated from the Illumina and Complete Genomics sequencing platforms.

Genome Raw Read Pre-processing

  • We perform a comprehensive analysis on all reads to gain understanding of the data set for each lane and run.

  • This facilitates the selection of high quality reads for feeding the pipeline.

  • Main analyses include:
    • Identification and removal of duplicate reads.
    • Analysis of quality scores.
    • Distribution of Ns and filtering.

  • We provide a complete pre-processing report for each genome.

Mapping

  • We utilise a proprietary mapping strategy using internally-developed software.

  • Key advantages of our mapping approach include exceptional speed and accuracy.

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Read Density CNV

  • Our service identifies copy number variation based on read density.

  • We use advanced algorithms to identify and rank read density edges.

  • We also perform an analysis between read density edges and structural variations.

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Detection of Structural Variations

  • We detect putative variations by identifying anomalous mappings of paired-end reads.

  • We subseqently filter and rank the variations using proprietary rules and algorithms.

  • Our pipeline is designed to handle:
    • Large-scale mutations (>1000bp) such as inversions, deletions and translocations.
    • Small-scale indels (10-1000bp) using a proprietary method based on read density.
    • Fusion genes.

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Detection of SNPs and Indels

  • Our pipeline consists of optimised algorithms and rules for detection of SNPs, even at low coverage.

  • SynaWorks' software increases accuracy of mapping, resulting in high numbers of true positives being identified.

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Visualisation

  • MGRC's Genome Browser is optimised to visualise processed next-generation data.

  • Our Browser is compatible with both of the following platforms:

    • Standalone personal computers running on Windows; and
    • Client server architecture using WAN or LAN.

  • Key features of the Genome Browser include:

    • Exceptional performance: high-speed browsing, searching and loading; locally and across WAN.

    • Multiple genome input: facilitates comparison.

    • Ease-of-use: system setup, sharing of experimental data and browsing.

    • Track personalisation: creates custom tracks.

    • Flexible data format: supports multiple data formats (.mod, .gff V3, .gft, .csv, tab delimited).

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Comparative Analysis





Intersection Analysis



Enquiry



Email us at                                                or submit the form below:
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Name* Email *
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Type of sequencing
Depth or coverage of sequencing Read
type		 Single Paired-end
Type of analysis
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Human Genome Informatics Service
Pre-processing
Mapping
SNPs/Indels
Structural variations
Comparative genomics
Browser
Transcriptome / Exome
Pre-processing
De novo assembly
Mapping
Gene expression analysis
Gene prediction
Browser
Other Services
De novo assembly
miRNA
Browser
Brief project synopsis
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