Kuala Lumpur, 24 April 2007 –
Synamatix announced today the release of two new software applications designed to process and analyse
data from large-scale re-sequencing projects conducted with second generation DNA sequencing platforms.
Robert Hercus, Synamatix Managing Director, commented, "SXOligosearch™ and a modified version
of SynaSearch™ have been released to address the growing explosion of data from the increasing
use of the 454-Roche and Solexa-Illumina DNA sequencing platforms.
These applications were developed as part of an ongoing strategy to complete a suite of
high-throughput applications to process, analyse and integrate data from every type of
second generation DNA sequencer."
The first application, SXOligosearch, is designed to map short sequences such as reads from the
Solexa-Illumina genome sequencer or oligonucleotide microarray probes. It offers a very high degree
of flexibility in terms of handling a wide variety of read errors or mutations. In addition, more
than a 100-fold improvement in performance compared to conventional tools is observed. Unlike other
industry standard alignment tools, SXOligosearch aligns complete reads rather than HSPs resulting in
higher specificity and sensitivity. It is also able to handle low-quality reads containing any number
of mismatches, insertions or deletions with high accuracy and superior performance.
A new version of SynaSearch, modified to process and map reads from the GS20 and FLX platforms from 454,
has also been released. Careful optimisation has resulted in increased accuracy, specificity and a
200-fold improvement in performance compared to standard approaches.
By using SynaBASE™ as a common platform, various types of reads can be mixed to increase coverage
and deepen support for differences that are identified between data sets.
Synamatix's other high-performance applications based upon SynaBASE, its unique structured network
database platform, include SynaTree™, SXPRESearch™ and SXProbeDB™.
About Synamatix
The fundamental technology underlying Synamatix software applications is the proprietary "SynaBASE"
platform. Applications built upon this database platform exhibit very significant improvement in
scalability, sensitivity and performance. Synamatix is a privately held next-generation bioinformatics
company whose primary activities are based upon ongoing R&D related to its core technology, development
of new software applications, and the support of its user base in the USA, Europe, Asia and Australia.
Contact
Patricia Chan
Marketing and Communications
Synamatix Sdn. Bhd.
enquiries@synamatix.com
www.synamatix.com