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Archived
- 2008
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Archived
- 2008
Scientists have successfully used exome sequencing to identify a previously unknown gene responsible for a mendelian disorder. The method involved sequencing only the protein-coding regions of the genome.
Publications
- 3' tag DGE profiling of human brain and universal reference RNA
- Comparative genomic and phylogeographic analysis of Mycobacterium leprae
- Accuracy of allele frequency estimates in pool DNA
- Cucumber genome sequencing
- Complete Genomics publishes report on low-cost human genome sequencing
- Scientists help unravel corn's genetic makeup
- Personal genome sequence is must-have accessory for billionaires
- Pigs join the ranks of domesticated animals with sequenced genomes
Researchers have discovered that the human genome is organised into two separate compartments, keeping active genes accessible while placing inactive DNA in 'storage'.
Publications
- Detecting species-site dependencies in large multiple sequence alignments
- Mutational evolution in a lobular breast tumour profiled at single nucleotide resolution
- Large scale single nucleotide polymorphism discovery in unsequenced genomes
- Whole-genome sequencing of two Kalahari Bushmen genomes
- Sequencing of infant's genome yields a surprise diagnosis
- First high-throughput analysis of every Salmonella typhi gene
- Establishing standard definitions for genome sequences
The Potato Genome Sequencing Consortium (PGSC) has released a draft of the potato genome. It is anticipated that the genome sequence will assist scientists in improving yield, quality, nutritional value and disease resistance in potato varieties.
Publications
- Allele-specific expression assays using Solexa
- High resolution genome sequencing of Influenza A viruses
- Ranking differentially expressed genes from Affymetrix data
- Polymorphic variants in hereditary pancreatic cancer genes are not associated with pancreatic cancer risk
- Cancer-killing gene found
- Gene study reveals Indian origins
- Ancient DNA offers clues to modern European ancestry
- New genes linked to Alzheimer's disease
An international research team has reported the first direct measurement of the general rate of genetic mutation at individual base level in humans by sequencing the Y chromosome from two men separated by 13 generations.
Publications
- High throughput sequencing in mice: a platform comparison identifies a preponderance of cryptic SNPs
- Comparative analysis of high-throughput molecular technologies for exploring intestinal microbiota
- Analysis of splicing patterns by pyrosequencing
- Illumina delivers its first personal genome
- Sequencing findings show diarrhoea disorder giardiasis caused by two different parasite species
- Complexity of cancer genomics revealed
- Scientists develop new method to detect copy number variants using DNA sequencing technologies
Scientists at Harvard Medical School have transformed self-serving E. coli cells into efficient factories by developing a new cell programming method which edits multiple genes in parallel.
Publications
- A highly annotated whole-genome sequence of a Korean individual
- Identification and characterization of novel amphioxus microRNAs by Solexa sequencing
- Mapping short reads from massively parallel sequencing for expression profiling
- Analysis of 5' transcript heterogeneity by high-throughput sequencing of cDNA
- New tools for discovering DNA variation in crop genomes
- Researchers to breed 'Super-Tuna' within a decade
- Mapping the crocodile genome
Scientists at CSHL have devised a genetic sequencing technique inspired by the popular puzzle, Sudoku. This method could reduce both time and costs in DNA sequencing in the near future.
Publications
- Closing the gaps in the human genome
- Genomic analysis of the microsporidian Nosema ceranae
- Multiplex sequencing to discover CNVs in Drosophila
- Deep sequencing technology reveals novel microRNAs in bread wheat
- Crop plants get genomics centre
- Sequencing of potato genome for better spuds
- Gene mutation in rare ovarian cancers
Synamatix, Sime Darby and 454 Life Sciences have jointly completed the sequencing, assembly and annotation of the oil palm genome.
Publications
- Fast and accurate short read alignment
- Whole genome sequencing of recombinant Toxoplasma gondii strain
- PanGEA: Identification of allele-specific gene expression
- Genome-wide massively parallel sequencing of FFPE tumor tissues
- Metagenomics study reveals diversity of human skin microbiome
- Whole genome sequencing approach for mutation discovery
- Mouse genome unveiled
Full DNA sequences taken from 34 virus samples have been posted online, giving scientists worldwide the chance to create new tools to fight the virus.
Publications
- Estimating accuracy of RNA-Seq and microarrays with proteomics
- Mining small sequencing data to identify small nucleolar RNAs
- Modifications bases in mRNAs and non-coding RNAs
- Using proteomics to evaluate accuracy of microarrays and RNA-seq
- New methods for sequencing-based methylation profiling
- Researchers reveal complete genetic sequence of the cow
- Physicists create novel technique to sequence human genome
Scientists at the Georgia Institute of Technology have used a new approach, known as RNA-Seq, to profile the gene expression of the anthrax-causing bacterium, Bacillus anthracis.
Publications
- High throughput sequencing of microRNAs in chicken somites
- Evaluation of NGS platforms for population studies
- Sequencing-by-synthesis method for improving sequence coverage uniformity
- Using ChIP-Seq to reveal nucleosome architecture of human promoters
- DNA sequencing using a scanning tunnelling microscope (STM)
- Calibrating high throughput sequencing platforms with digital PCR
- Studying DNA landscape to detect functional genomic regions
A team of scientists from Germany has sequenced more than one billion DNA fragments extracted from three Croatian Neanderthal fossils.
Publications
- Identifying human chromatin interactions using ChIP-based methods
- ARGOT method for rapid annotation of anonymous sequences
- Deducing structural variants from massive paired-end sequencing data
- BioNanomatrix's pursuit of the $100 genome
- Genomes of common cold virus sequenced
- Sequencing technology to pinpoint 'on-off switches' in genomes
A team of scientists has analysed the mitochondrial genome of the Tasmanian tiger to determine reasons that led to the species' extinction.
Publications
- Heat treatment optimises 454 sequencing library preparation
- Scientists develop 5'-end transcriptome workflow for SOLiD system
- Researchers design multiplex short-read DNA sequencing method for efficient yeast ChIP-Seq
- PeakSeq claimed to optimise ChIP-Seq data analysis
- Gene fusion linked to cancer development
- Oxford Nanopore signs next-gen sequencing deal with Illumina
- Team uses 454's FLX system to study HIV tropism
A joint team from the Korean Bioinformation Center and Gachon University of Medicine and Science has sequenced the whole personal genome of a local researcher...
Publications
- Comparing platforms for high-throughput whole-genome sequencing
- Analysis of BP1 transcriptional targets in breast cancer cell
- High quality draft genome sequences using a mix of sequencing technologies
- DNA sequencing technologies for analysis of gene expression
- Draft genome of the soya bean has been released
- SEQC - the Sequencing Quality Control Project
