Our Contract Genomics Services are provided as an end-to-end package which is designed to enable customers to fully leverage our comprehensive applications, pipelines and expertise. It is customised for each customer's needs to provide results that are optimised and is cost saving in terms of resources, time and manpower. By relying on our extensive know-how of next generation sequencing informatics, customers can stay focused on their core business or research.

Key capabilities of MGRC Analysis Pipelines include:

• Human Genome Bioinformatics Service
We map sequenced data up to 30 times the coverage of the human genome, identify mutations and present the results and findings in a compact report and via an online browser. This service is specifically designed for data generated from the Illumina, Complete Genomics or SOLiD sequencing platform. Click here for more information.


• Genome Re-sequencing
The analysis that is carried out on newly-sequenced genomes is based primarily on the analysis of differences and similarities to a reference genome. This is critical for associating the differences and similarities to a biological function. MGRC uses integrated software pipelines and algorithms to identify these differences or mutations with high speed, accuracy and confidence.


• Transcriptome Sequencing Analysis
MGRC's transcriptome sequencing analysis services include the identification of SNPs, insertions and deletions, and the analysis of differential gene expression.


• ChIP-Seq Analysis
ChIP-Seq is a powerful technique to identify regions of DNA that are bound to a specific protein. The analysis on ChIP-Seq sequence data is based on identifying the protein-binding sites, by searching for peaks within the data.


• De Novo Assembly
Genome assembly is perhaps the most complex of bioinformatics processes and involves very significant resources in terms of customised bioinformatics pipelines and software algorithms. The process involves identifying overlaps between short DNA sequence reads and then progressively building longer pieces or contigs until the longest possible piece is made.


• MicroRNA Analysis
MicroRNAs are short fragments of RNA that have been shown to be involved in regulation of genes. As they have complex structures and sequences, key steps of downstream bioinformatics analysis involve identification of the types of genes microRNAs may interact with. This is achieved by using bioinformatics software and algorithms to align and match microRNA sequences with genes.


• Mutation Analysis
Mutations are essentially differences between a reference, or known, genome or transcriptome, and a newly-sequenced sample. These differences can be anywhere from a single DNA base, to hundred, thousands or millions of bases of DNA. Mutations include single-base substitutions called SNPs, as well as insertions, deletions, inversions and translocations of varying sizes of DNA. Another major class of mutations are termed copy number variations, as they result in amplification or reduction of specific sections of DNA. MGRC utilises integrated software pipelines and algorithms to identify the differences or mutations with high speed, accuracy and confidence.


• Annotation Services
Annotation is the assignment of function to regions of DNA in the genome or transcriptome of a novel organism. It is carried out using a battery of software algorithms which identifies genes, promoters, splice variants and other functional domains.

MGRC provides high-throughput sequencing services for genomes and transcriptomes. Our sequencing services are highly customised to suit your research needs. Two key advantages that we offer are versatility and technical expertise. Samples are sequenced using one of two available next generation sequencing platforms - 454 Life Sciences and Illumina - current market leaders in the DNA sequencing industry. MGRC's services are backed by a team of bioinformaticians, thus ensuring that all projects are monitored and conducted by experts in the business.

Our sequencing services generate terabytes of data within a relatively short span of time. As a result of next generation sequencing technology, the data comprises a greater number of sequencing reads with longer read lengths. This also means that sequenced data can be obtained at lower costs within a shorter period of time. We have extensive experience in sequencing the genomes of a wide array of organisms, including human cancers and oil palm. We have also been involved in sequencing projects relating to biomedical and healthcare research.

Key applications of MGRC's sequencing services include:

• Whole genome de novo sequencing, re-sequencing and targeted sequencing
• mRNA sequencing
• Small RNA discovery
• Exome sequencing
• Methylation sequencing
• ChIP sequencing (protein-DNA interactions)
• Multiplexing of several small genomes with a single experiment

Our Data and Access Services primarily serves to provide the worldwide life sciences community access to cutting-edge sequence analysis tools via our online bioinformatics portal. These tools enable researchers and students alike to conduct a wide array of research activities ranging from high-throughput genomics searches and mining, identification of novel data hits and motifs through to more exhaustive whole genome comparisons and microarray chip design.

With the support that MGRC receives from the Malaysian Biotechnology Corporation, this service is provided to the public at no cost. Please click here for more information on our sequence analysis tools and to experience them online.