Understanding four new genes for Alzheimer’s disease through SynaBlast-Mega, a bulk search application
Researchers from a consortium of 44 universities and research institutions in the United States have identified four new genes linked to Alzheimer’s disease (AD). These genes could provide clues to the causes of the disease and subsequently lead to the discovery of more effective drugs to treat or cure this degenerative disease. Genetic studies could also help scientists better understand the mechanisms that occur in the brain even before the symptoms are observed.
The genes mentioned in the paper are MS4A, CD2AP, CD33, and EPHA1.
SynaBlast-Mega™ is a multiple sequence alignment tool that enables users to search for several protein or nucleotide sequences simultaneously. This tool makes it easier for researchers to analyse bulk sequences as it allows the submission of numerous sequences at any given time. Comprehensive alignment options are provided and the final results are presented in various alignment output formats. Researchers can use this application to discover protein homologs within other species of the multiple AD-susceptibility genes. This information would add value to studies on AD progression that use model organisms.